Biosimilars Quiz

Which of the following statements regarding biosimilar development is incorrect? #EULAR2017

1. All biologic medicines have batch-to-batch variability
2. The variability of the reference medicine defines the target range for development of a biosimilar
3. The structure and functionality of a biosimilar can vary from the reference medicine
4. High levels of comparability must be demonstrated at analytical, biological, preclinical, and clinical levels